As DNA profiling methods have become ever more sensitive, the detection of trace amounts of DNA has significantly improved. As a result, the number of DNA mixtures we encounter has increased. This was especially highlighted following the introduction of DNA17 methods in 2014. In many situations the mixtures have multiple contributors and are complex to interpret. Whilst previously many results were designated as too complex for interpretation, the last few years have seen the introduction of ‘probabilistic genotyping software’ packages which enable a statistical evaluation of complex results.